解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Prostaglandin E₂ (PGE₂) is an arachidonic acid (AA)-derived signaling molecule that can influence host immune responses to infection or vaccination. In this study, we investigated PGE₂ production in vitro by cells infected with the poxvirus vaccine strain, modified vaccinia Ankara virus (MVA). Human THP-1 cells, murin...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.03.019
更新日期:2012-07-05 00:00:00
abstract::Circomics was coined to describe the combination of rolling circle amplification (RCA), restriction fragment length polymorphism (RFLP) and pyro-sequencing to investigate the genome structures of small circular DNAs. A batch procedure is described using 61 plant samples from Asia, South America and Central America whi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.02.007
更新日期:2012-06-05 00:00:00
abstract::To identify new genes affecting Tomato bushy stunt virus (TBSV) replication in yeast model host, we are studying protein families, whose members have been identified during previous high throughput screening. In this paper, we have characterized the WW domain-containing protein family from yeast and plants. We find th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.01.020
更新日期:2012-05-10 00:00:00
abstract::Wasting is a sign of various underlying disorders and is a common feature of cancer, sepsis, and AIDS. We have developed an in vivo model to study the various stages of wasting following infection of mice with lymphocytic choriomeningitis virus cl-13. Using this model we have identified four distinct stages of wasting...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.01.005
更新日期:2012-04-10 00:00:00
abstract::The Rice stripe virus (RSV) pc4 has been determined as the viral movement protein (MP). In this study, the pc4 gene was cloned into a movement-deficient Tobacco mosaic virus (TMV). The resulting hybrid TMV-pc4, in addition to spreading cell to cell in Nicotiana tabacum, moved systemically and induced foliar necrosis i...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.01.007
更新日期:2012-04-10 00:00:00
abstract::Alternations of cellular gene expression following an adenovirus type 2 infection of human primary cells were studied by using superior sensitive cDNA sequencing. In total, 3791 cellular genes were identified as differentially expressed more than 2-fold. Genes involved in DNA replication, RNA transcription and cell cy...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.12.006
更新日期:2012-03-15 00:00:00
abstract::In 2006, an exotic reassortant orbivirus, epizootic hemorrhagic disease virus serotype 6 (EHDV-6) [strain (Indiana)], was first detected in the United States. To characterize the reassortment configuration of this virus and to conclusively determine the parental virus of each RNA segment, the complete genome of EHDV-6...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.12.004
更新日期:2012-03-01 00:00:00
abstract::HIV-1 Vpu antagonizes the block to particle release mediated by CD317 (BST-2/HM1.24/Tetherin) via incompletely understood mechanisms. Vpu and CD317 partially reside in cholesterol-rich lipid rafts where HIV-1 budding preferentially occurs. Here we find that lipid raft association of ectopically expressed or endogenous...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.12.008
更新日期:2012-03-01 00:00:00
abstract::Puumala (PUUV) and Hantaan (HTNV) viruses are hantaviruses within the family Bunyaviridae and associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in humans. Little is known about how these viruses interact with host cells, though pathogenic hantaviruses interact with α(v)β(3) integrin. To study host cell inte...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.08.012
更新日期:2012-02-20 00:00:00
abstract::Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is a...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2011.11.016
更新日期:2012-02-05 00:00:00
abstract::Following an increase in detection of enterovirus 68 (EV68) in community surveillance of respiratory infections in The Netherlands in 2010, epidemiological and virological analyses were performed to investigate the possible public health impact of EV68 infections. We retrospectively tested specimens collected from acu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.11.021
更新日期:2012-02-05 00:00:00
abstract::H4N8 subtype avian influenza viruses were isolated from shorebirds in eastern Hokkaido. All the isolates shared >99.7% nucleotide homology, and all the viral genes except for PB1 were highly related to those of A/red-necked stint/Australia/1/04. Thus, the isolates were regarded as PB1 reassortants. The most similar PB...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.11.019
更新日期:2012-02-05 00:00:00
abstract::The HIV-1 Tat protein is released by infected cells and has numerous biological activities which might contribute either to the impairment of the immune response or to viral dissemination and pathogenesis. To date, the effects of Tat protein on metabolites remain unclear. In this study, a metabolomic study on serum of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.11.005
更新日期:2012-01-20 00:00:00
abstract::The influenza virus mRNAs are structurally similar to cellular mRNAs nevertheless; the virus promotes selective translation of viral mRNAs despite the inhibition of host cell protein synthesis. The infection proceeds normally upon functional impairment of eIF4E cap-binding protein, but requires functional eIF4A helica...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.10.028
更新日期:2012-01-20 00:00:00
abstract::Repression of human papillomavirus (HPV) E6 and E7 oncogenes in established cervical carcinoma cell lines causes senescence due to reactivation of cellular tumor suppressor pathways. Here, we determined whether ongoing expression of HPV16 or HPV18 oncogenes is required for the proliferation of primary human cervical c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.10.012
更新日期:2012-01-05 00:00:00
abstract::Enterovirus 71 (EV71) is a major cause of hand-foot-and-mouth disease. EV71 infection occasionally associates with severe neurological sequelae such as brainstem encephalitis or poliovirus-like paralysis. We demonstrated that mouse-adapted strain increases infectivity, resulting in higher cytotoxicity of neuron cells ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.10.015
更新日期:2012-01-05 00:00:00
abstract::Sindbis virus (SINV) induces inflammatory and vasoactive responses that are associated with rash and arthritis in human infections. The mechanisms underlying infection-associated microvasculopathy are still unknown. We investigated whether endothelial cells infected by SINV are differentially responsive to bradykinin ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.10.003
更新日期:2012-01-05 00:00:00
abstract::The P1 plasmid partition system depends on ParA-ParB proteins acting on centromere-like parS sites for a faithful plasmid segregation during the Escherichia coli cell cycle. In vivo we placed parS into host E. coli chromosome and on a Sop(+) F plasmid and found that the stability of a P1 plasmid deleted for parA-parB ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.09.027
更新日期:2011-12-20 00:00:00
abstract::We previously described a single-cycle dengue vaccine (RepliVAX D2) engineered from a capsid (C) gene-deleted West Nile virus (WNV) expressing dengue virus serotype 2 (DENV2) prM/E genes in place of the corresponding WNV genes. That work demonstrated that adaptation of RepliVAX D2 to grow in WNV C-expressing cells res...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.09.007
更新日期:2011-12-20 00:00:00
abstract::IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.09.006
更新日期:2011-12-05 00:00:00
abstract::The Human Papillomavirus type-16 (HPV-16) E6 and E7 oncogenes are selectively retained and expressed in cervical carcinomas, and expression of E6 and E7 is sufficient to immortalize human cervical epithelial cells. Expression of the epidermal growth factor receptor (EGFR) is often increased in cervical dysplasia and c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.09.014
更新日期:2011-12-05 00:00:00
abstract::We used Cre/loxP recombination to swap targeting ligands present on the adenoviral capsid protein IX (pIX). A loxP-flanked sequence encoding poly-lysine (pK-binds heparan sulfate proteoglycans) was engineered onto the 3'-terminus of pIX, and the resulting fusion protein allowed for routine virus propagation. Growth of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.09.004
更新日期:2011-11-25 00:00:00
abstract::It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.08.010
更新日期:2011-10-25 00:00:00
abstract::During replication of human parainfluenza virus type 3 (HPIV3), the 96-nucleotide antigenomic promoter (AGP) of HPIV3 directs the synthesis of genomic RNA. Previous work showed that nucleotides 1-12 were critical in promoting replication of an HPIV3 minireplicon, but nucleotides 13-96 were not investigated. In this st...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.08.003
更新日期:2011-10-25 00:00:00
abstract::Little is known about the molecular determinants causing and sustaining viral persistent infections at the cellular level. We found that Drosophila cells persistently infected (PI) with Flock House virus (FHV) invariably harbor defective viral RNAs, which are replicated by the FHV RNA-dependent RNA polymerase. Some de...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.08.002
更新日期:2011-10-10 00:00:00
abstract::The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins (A3A-H) are known to restrict various retroviruses and retroelements, but the full complement of rhesus macaque A3 proteins remains unclear. We report the isolation and characterization of the hA3A homologue from r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.07.017
更新日期:2011-10-10 00:00:00
abstract::While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susce...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.07.010
更新日期:2011-09-15 00:00:00
abstract::HPV16 E6 deregulates G1/S cell cycle progression through p53 degradation preventing transcription of the CDK inhibitor p21(WAF1). However, additional mechanisms independent of p53 inactivation appear to exist. Here, we report that HPV16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) tr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.05.016
更新日期:2011-09-01 00:00:00
abstract::Assembly of icosahedral capsids of proper size and symmetry is not understood. Residue F170 in bacteriophage P22 coat protein is critical for conformational switching during assembly. Substitutions at this site cause assembly of tubes of hexamerically arranged coat protein. Intragenic suppressors of the ts phenotype o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.06.025
更新日期:2011-09-01 00:00:00
abstract::Tetherin (ST2/CD317) is a cellular protein that restricts the release from cells of some enveloped viruses including HIV-1. To examine if influenza virus is affected by tetherin, MDCK cells constitutively expressing human tetherin and control MDCK cells were infected with influenza virus. No difference was observed in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.05.006
更新日期:2011-08-15 00:00:00
abstract::A crucial step in the arenavirus life cycle is the proteolytic processing of the viral envelope glycoprotein precursor (GPC) by the cellular proprotein convertase (PC) subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P). Here we conducted a systematic and quantitative analysis of SKI-1/S1P processing of peptides ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.04.021
更新日期:2011-08-15 00:00:00
abstract::West Nile virus (WNV) has become firmly established in northeastern US, reemerging every summer since its introduction into North America in 1999. To determine whether WNV overwinters locally or is reseeded annually, we examined the patterns of viral lineage persistence and replacement in Connecticut over 10 consecuti...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.06.006
更新日期:2011-08-15 00:00:00
abstract::While the C-terminal domain of HIV-1 Vpu is critical for CD4 degradation, the transmembrane domain (TM) mediates ion channel activity, enhances virus release and is essential for counteracting CD317/Bst-2/Tetherin. Here we analyzed whether the ion channel activity of Vpu is required to antagonize CD317-mediated restri...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.04.009
更新日期:2011-07-20 00:00:00
abstract::Adenoviruses with deletion of E1b have been used in clinical trials to treat cancers that are resistant to conventional therapies. The efficacy of viral replication within cancer cells determines the results of oncolytic therapy, which remains poorly understood and requires further improvement. In this report, we show...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.04.017
更新日期:2011-07-20 00:00:00
abstract::The requirement to replicate in both vertebrate and invertebrate hosts is thought to limit the introduction of genetic changes into the genome of arboviruses. Serial passage under laboratory conditions will overcome this limitation allowing for genetic changes to be introduced and affecting the virulence of the virus ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.030
更新日期:2011-06-20 00:00:00
abstract::It has been shown that the genomes of episomally maintained DNA viruses are tethered to host cell chromosomes during cell division, facilitating maintenance in dividing cells. The papillomavirus E2 protein serves this mechanism of viral genome persistence by simultaneously associating with chromatin and the viral geno...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.015
更新日期:2011-05-25 00:00:00
abstract::Here we completed the whole genome sequence of Cotesia vestalis bracovirus (CvBV) by deep sequencing and compared the genome features of CvBV to those of other polydnaviruses (PDVs). The genome is 540,215 base pairs divided into 35 genomic segments that range from 2.6 to 39.2kb. Comparison of CvBV with other PDVs show...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.009
更新日期:2011-05-25 00:00:00
abstract::We have utilized glycan microarray technology to determine the receptor binding properties of early isolates from the recent 2009 H1N1 human pandemic (pdmH1N1), and compared them to North American swine influenza isolates from the same year, as well as past seasonal H1N1 human isolates. We showed that the pdmH1N1 stra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.01.027
更新日期:2011-05-10 00:00:00
abstract::Human infections with highly pathogenic H5N1 avian influenza viruses continue to occur in many parts of the world and pose a considerable public health threat. With the use of animal models, the identification of virulence determinants has been instrumental in improving our understanding of how these viruses cause sev...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.02.005
更新日期:2011-05-10 00:00:00
abstract::Two small viral proteins (DGBp1 and DGBp2) have been proposed to act in a concerted manner to aid intra- and intercellular trafficking of carmoviruses though the distribution of functions and mode of action of each protein partner are not yet clear. Here we have confirmed the requirement of the DGBps of Pelargonium fl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.001
更新日期:2011-05-10 00:00:00